KCNQ Channels Determine Serotonergic Modulation of Ventral Surface Chemoreceptors and Respiratory Drive
نویسندگان
چکیده
منابع مشابه
HCN channels contribute to serotonergic modulation of ventral surface chemosensitive
1 2 HCN channels contribute to serotonergic modulation of ventral surface chemosensitive 3 neurons and respiratory activity. 4 5 Virginia E. Hawkins 1* , Joanna M. Hawryluk 1* , Ana C. Takakura 2 , Anastasios V. Tzingounis 1 , 6 Thiago S. Moreira 3 , Daniel K. Mulkey 1 7 8 1 Dept. of Physiology and Neurobiology, Univ. of Connecticut, Storrs, CT 06269, USA 9 2 Dept. of Pharmacology, Univ. of Sao...
متن کاملHCN channels contribute to serotonergic modulation of ventral surface chemosensitive neurons and respiratory activity.
Chemosensitive neurons in the retrotrapezoid nucleus (RTN) provide a CO2/H(+)-dependent drive to breathe and function as an integration center for the respiratory network, including serotonergic raphe neurons. We recently showed that serotonergic modulation of RTN chemoreceptors involved inhibition of KCNQ channels and activation of an unknown inward current. Hyperpolarization-activated cyclic-...
متن کاملO3: Pharmacological Modulation of Thalamic KCNQ-Potassium Channels: Insight from Knock-out Mice
The channels belonging to the KCNQ gene family consist of 5 different subtypes, which assemble as pentameric channels. The KCNQ2-5 subunits are highly expressed in the ventrobasal thalamus (VB) where they function primarily as KCNQ2/3 heteromers. They underlie an outward potassium (K+)-current, called M-current (IM), which provides a hyperpolarizing drive, thus regulating neuronal excitability....
متن کاملRegulation of ventral surface chemoreceptors by the central respiratory pattern generator.
The rat retrotrapezoid nucleus (RTN) contains neurons described as central chemoreceptors in the adult and respiratory rhythm-generating pacemakers in neonates [parafacial respiratory group (pfRG)]. Here we test the hypothesis that both RTN and pfRG neurons are intrinsically chemosensitive and tonically firing neurons whose respiratory rhythmicity is caused by a synaptic feedback from the centr...
متن کاملPeripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO2 : role of carotid body CO2.
We asked if the type of carotid body (CB) chemoreceptor stimulus influenced the ventilatory gain of the central chemoreceptors to CO2 . The effect of CB normoxic hypocapnia, normocapnia and hypercapnia (carotid body PCO2 ≈ 22, 41 and 68 mmHg, respectively) on the ventilatory CO2 sensitivity of central chemoreceptors was studied in seven awake dogs with vascularly-isolated and extracorporeally-p...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3043-12.2012